Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	GlmnGt(OST109778)Lex
Name:	glomulin, FKBP associated protein; gene trap OST109778, Lexicon Genetics
MGI ID:	MGI:3817643
Gene:	Glmn  Location: Chr5:107696833-107745754 bp, - strand  Genetic Position: Chr5, 52.23 cM
Alliance:	GlmnGt(OST109778)Lex page

Mutant Cell Line:	OST109778
Germline Transmission:	Earliest citation of germline transmission: J:184206
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The Lexicon Genetics gene trap vector VICTR48, which contains a splice acceptor sequence followed by the neomycin resistance gene and a double polyadenylation signal, has integrated into the first intron of the glomulin gene upstream of the translation initiation site, which resides in the second exon (Genbank accession NM_133248.1). Western blot analysis confirmed the absence of protein expression in the yolk sac. (J:184206) Inheritance:    Recessive Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST109778 CG529399 (MGI Seq Detail) 3' RACE Chr5:107721703-107744694 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 5 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Glmn Mutation:	35 strains or lines available

Original:	J:184206 Tron AE, et al., The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78
All:	2 reference(s)