Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpr15tm1.1Litt
Name:	G protein-coupled receptor 15; targeted mutation 1.1, Dan R Littman
MGI ID:	MGI:3815547
Synonyms:	Gpr15gfp
Gene:	Gpr15  Location: Chr16:58537796-58539433 bp, - strand  Genetic Position: Chr16, 34.83 cM
Alliance:	Gpr15tm1.1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:199126
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 was replaced by GFP and SV40polyA followed by a loxP-flanked neomycin resistance cassette. The neomycin cassette was later removed by Cre treatment. RT-PCR confirmed the absence of transcript expression in the large intestine lamina propria and spleen. (J:199126)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr15 Mutation:	30 strains or lines available

Original:	J:199126 Kim SV, et al., GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013 Jun 21;340(6139):1456-9
All:	9 reference(s)