Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgdibtm1Miyo
Name:	Rho, GDP dissociation inhibitor beta; targeted mutation 1, Jun Miyoshi
MGI ID:	MGI:3814585
Synonyms:	RhoGDIbeta, Rho GDIbeta
Gene:	Arhgdib  Location: Chr6:136900653-136918895 bp, - strand  Genetic Position: Chr6, 66.72 cM, cytoband G1
Alliance:	Arhgdibtm1Miyo page

Germline Transmission:	Earliest citation of germline transmission: J:140671
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.7-kb DNA region covering the promoter region and exons 1 and 2 of the gene locus was replaced by a neomycin resistance cassette. Gene inactivation was confirmed by immunoblot assay on T and B lymphocyte cells collected from the spleen (J:140671)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgdib Mutation:	16 strains or lines available

Original:	J:140671 Ishizaki H, et al., Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta. J Immunol. 2006 Dec 15;177(12):8512-21
All:	1 reference(s)