Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Tva)Dsa
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Dieter Saur
MGI ID:	MGI:3814188
Synonyms:	LSL-R26lacZ, LSL-R26Tva-lacZ, R26LSL-TVA, R26LSL-TVAilacZ
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Tva)Dsa page

Germline Transmission:	Earliest citation of germline transmission: J:140423
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: The tumor virus A (Tva) sequence disrupted with a lox-stop-lox cassette after the initiation codon, an IRES element and lacZ were inserted into intron 1 via homologous recombination. Cre mediated recombination results in expression of TVA and lacZ. Expression of TVA makes cells vulnerable to infection by RCAS (replication-competent sarcoma-leukosis virus long terminal repeat with splice acceptor) vector with Bryan-RSV polymerase and subgroup A envelope viruses (RCASBP(A)). (J:140423)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(Tva)Dsa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:140423 Seidler B, et al., A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10137-42
All:	24 reference(s)