Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tet2Gt(Ayu17-449)Imeg
Name:	tet methylcytosine dioxygenase 2; gene trap Ayu17-449, Institute of Molecular Embryology and Genetics
MGI ID:	MGI:3813933
Gene:	Tet2  Location: Chr3:133169438-133250882 bp, - strand  Genetic Position: Chr3, 61.84 cM
Alliance:	Tet2Gt(Ayu17-449)Imeg page

Mutant Cell Line:	Ayu17-449
Germline Transmission:	Earliest citation of germline transmission: J:140275
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Gene trapped (RMCE-ready) Mutations:    Insertion of gene trap vector, Intragenic deletion   Mutation details: The gene trap vector pUC17, which contains an En splice acceptor, lox71 site, lacZ gene, neo cassette, loxP site and lox2272 site, was inserted into intron 2 upstream of the translation initiation codon in exon 3. Insertion of the gene trap vector using cre mediated cassette exchange results in the deletion of 10 bp. The absence of transcript expression was confirmed by RT-PCR. (J:140275)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Tet2Gt(Ayu17-449)Imeg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tet2 Mutation:	778 strains or lines available

Original:	J:140275 Tang H, et al., Characterization of Ayu17-449 gene expression and resultant kidney pathology in a knockout mouse model. Transgenic Res. 2008 Aug;17(4):599-608
All:	13 reference(s)