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Gjb4tm1Kwi
Targeted Allele Detail
Summary
Symbol: Gjb4tm1Kwi
Name: gap junction protein, beta 4; targeted mutation 1, Klaus Willecke
MGI ID: MGI:3811558
Synonyms: Cx30.3-, Cx30.3LacZ
Gene: Gjb4  Location: Chr4:127244879-127247874 bp, - strand  Genetic Position: Chr4, 61.51 cM, cytoband D1-D3
Alliance: Gjb4tm1Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140005
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene with a nuclear localization signal followed by a frt-flanked neomycin selection cassette in the reverse transcriptional orientation was inserted into the starting codon of the gene locus. Founder mice were crossed with a FLP-deleter strain to remove the neomycin selection cassette. Gene inactivation was confirmed by immunoblot analysis of skin lysates. LacZ expression was detected in the skin, kidney, and a subpopulation of cells in the apical layer of the vomeronasal organ. (J:140005)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb4 Mutation:  17 strains or lines available
References
Original:  J:140005 Zheng-Fischhofer Q, et al., Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction. Eur J Cell Biol. 2007 Dec;86(11-12):683-700
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory