Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syne2tm1Ngl
Name:	spectrin repeat containing, nuclear envelope 2; targeted mutation 1, Angelika A Noegel
MGI ID:	MGI:3811076
Synonyms:	Nesprin-2deltaABD
Gene:	Syne2  Location: Chr12:75865092-76157702 bp, + strand  Genetic Position: Chr12, 33.11 cM
Alliance:	Syne2tm1Ngl page

Germline Transmission:	Earliest citation of germline transmission: J:139778
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 4 were replaced with a neo cassette eliminating more than half of the actin binding domain. (J:139778)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syne2 Mutation:	297 strains or lines available

Original:	J:139778 Luke Y, et al., Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci. 2008 Jun 1;121(Pt 11):1887-98
All:	2 reference(s)