Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Itm2btm1Ldad
Name:	integral membrane protein 2B; targeted mutation 1, Luciano D'Adamio
MGI ID:	MGI:3810986
Gene:	Itm2b  Location: Chr14:73599666-73622729 bp, - strand  Genetic Position: Chr14, 38.88 cM
Alliance:	Itm2btm1Ldad page

Germline Transmission:	Earliest citation of germline transmission: J:138796
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted 200 bp 5' of exon 2 and a floxed PGK-neo cassette was inserted in intron 2 via homologous recombination. The floxed PGK-neo cassette was deleted via in vivo Cre-mediated recombination, leaving exon 2 floxed. (J:138796)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itm2b Mutation:	18 strains or lines available

Original:	J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
All:	3 reference(s)