Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm6(Map3k14*)Rsky
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Klaus Rajewsky
MGI ID:	MGI:3809723
Synonyms:	R26StopFLNikdeltaT3
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm6(Map3k14*)Rsky page

Germline Transmission:	Earliest citation of germline transmission: J:139293
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm6(Map3k14*)Rsky expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Map3k14 (MGI:1858204)   Mutation details: The gene lacking the sequence that encodes the TRAF3-binding domain, preceded by a floxed neo STOP cassette and followed by an frt-flanked IRES-EGFP cassette, was knocked into the locus to achieve cre-inducible, ubiquitous expression. Cre mediated removal of the STOP cassette is required for expression. (J:139293, J:157820)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:139293 Sasaki Y, et al., NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10883-8
All:	11 reference(s)