Vwa1tm1Jfba
Targeted Allele Detail
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| Symbol: |
Vwa1tm1Jfba |
| Name: |
von Willebrand factor A domain containing 1; targeted mutation 1, John F Bateman |
| MGI ID: |
MGI:3809230 |
| Synonyms: |
Vwa1betagal |
| Gene: |
Vwa1 Location: Chr4:155852952-155859042 bp, - strand Genetic Position: Chr4, 87.31 cM, cytoband E2
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| Alliance: |
Vwa1tm1Jfba page
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Collagen VI matrix is disorganized and reduced in the Vwa1tm1Jfba/Vwa1tm1Jfba sciatic nerve endoneurial matrix
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:139369
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The open reading frame was replaced LacZ gene with a nuclear localization signal and a floxed neo cassette. The expression of the reporter gene from the Vwa1 locus in heterozygous mice recapitulated gene expression in wild type mice. Northern blot analysis of total RNA extracted from spinal cord and brain demonstrated that the gene transcript is undetectable in homozygous mutant mice. The encoded protein was undetectable in nerve lysates by immunoblotting and in sections of sciatic nerve by immunofluorescence staining.
(J:139369, J:149746)
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Generation of the Vwa1tm1Jfba allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Vwa1 Mutation: |
38 strains or lines available
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| Original: |
J:139369 Allen JM, et al., The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes. Matrix Biol. 2008 May;27(4):295-305 |
| All: |
2 reference(s) |
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Analysis Tools
