Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tg(H2-L-IL6)1Kish
Name:	transgene insertion 1, Tadamitsu Kishimoto
MGI ID:	MGI:3806003
Synonyms:	H-2Ld-hIL6 tg, IL-6 tgm, Ld-IL-6
Transgene:	Tg(H2-L-IL6)1Kish  Location: unknown  Genetic Position: Chr9, Syntenic
Alliance:	Tg(H2-L-IL6)1Kish page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(H2-L-IL6)1Kish expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human IL6 (3569) Il6  (MGI:96559)   Mutation details: A transgenic construct containing the human IL6 gene and rabbit beta-globin sequence under the control of the mouse H-2Ld promoter was injected into fertilized C57BL/6 mouse eggs. Human IL6 protein is detected in serum by ELISA. mRNA is detected in the spleen, lymph nodes, thymus, heart, lung, liver, kidney, and intestine, but not in brain tissue. (J:40405, J:138762)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:138762 Kishimoto T, Generation of H2-L-IL6 transgenic mice. MGI Direct Data Submission. 2008;
All:	7 reference(s)