Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc35d3IAP
Name:	solute carrier family 35, member D3; intracisternal A particle insertion
MGI ID:	MGI:3802578
Synonyms:	Roswell, Slc35d3-, Slc35d3ros
Gene:	Slc35d3  Location: Chr10:19723662-19727205 bp, - strand  Genetic Position: Chr10, 9.12 cM, cytoband A2
Alliance:	Slc35d3IAP page

Strain of Origin:

C3H/HeSn-Rab27aash/JRos

Allele Type:    Spontaneous Mutations:    Insertion, Intragenic deletion   Mutation details: 468 bp of endogenous sequence in exon 1 was replaced with a 39 bp intracisternal A particle (IAP) sequence resulting in a new translation initiation methionine codon and substitution of 7 new amino acids for 10 endogenous amino acids at the N-terminus (MRQLCRGRVL becomes MWGRLPT). No gain of function effect is observed as in other spontaneous mutations derived from IAP insertion. (J:137593)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc35d3 Mutation:	12 strains or lines available

Original:	J:137593 Chintala S, et al., The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules. Blood. 2007 Feb 15;109(4):1533-40
All:	4 reference(s)