Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargc1btm1.1Dpk
Name:	peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Daniel P Kelly
MGI ID:	MGI:3802519
Synonyms:	PGC-1beta-
Gene:	Ppargc1b  Location: Chr18:61431207-61533502 bp, - strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Ppargc1btm1.1Dpk page

Germline Transmission:	Earliest citation of germline transmission: J:137598
Parent Cell Line:	SCC10 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre-mediated recombination was used to remove exons 4 through 6. Removal of these exons results in a frame shift and a premature STOP codon in exon 7. The absence of protein product was confirmed by western blot analysis on heart extracts. (J:137598)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppargc1b Mutation:	56 strains or lines available

Original:	J:137598 Lai L, et al., Transcriptional coactivators PGC-1{alpha} and PGC-l{beta} control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008 Jul 15;22(14):1948-61
All:	4 reference(s)