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Chd2Gt(RRBO46)Byg
Gene trapped Allele Detail
Summary
Symbol: Chd2Gt(RRBO46)Byg
Name: chromodomain helicase DNA binding protein 2; gene trap RRB046, BayGenomics
MGI ID: MGI:3800602
Synonyms: Chd2m, Chd2mut
Gene: Chd2  Location: Chr7:73076400-73191494 bp, - strand  Genetic Position: Chr7, 41.85 cM
Alliance: Chd2Gt(RRBO46)Byg page
Mutation
origin
Mutant Cell Line:  RRB046
Germline Transmission:  Earliest citation of germline transmission: J:146743
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector containing a lacZ and neo cassette inserted into intron 27. RT-PCR confirmed the lack of trancripts containing exons 26 through 29, and western blot analysis confirmed the expression of the beta-galactosidase fusion protein. (J:146743)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 24 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chd2 Mutation:  189 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:146743 Marfella CG, et al., Mutation of the SNF2 family member Chd2 affects mouse development and survival. J Cell Physiol. 2006 Oct;209(1):162-71
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory