Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2l11tm2Rjd
Name:	BCL2 like 11; targeted mutation 2, Roger J Davis
MGI ID:	MGI:3800457
Synonyms:	Bim3SA
Gene:	Bcl2l11  Location: Chr2:127967958-128004467 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Alliance:	Bcl2l11tm2Rjd page

Germline Transmission:	Earliest citation of germline transmission: J:137061
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A floxed neo cassette was inserted within intron 4, and specific mutations in exon 3 were introduced by homologous recombination. Mutations resuted in three sites of MAPK phosphorylation (Ser-55, Ser-65, and Ser-73) in exon 3 to be substituted with alanines (S55A, S65A, S73A). The neo cassette was then excised with cre recombinase leaving a single loxP site in intron 4. Expression of normal amounts of mutant proteins was confirmed by immunoblot. (J:137061)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:	32 strains or lines available

Original:	J:137061 Hubner A, et al., Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell. 2008 May 23;30(4):415-25
All:	3 reference(s)