Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrxn1tm2Sud
Name:	neurexin I; targeted mutation 2, Thomas C Sudhof
MGI ID:	MGI:3797417
Synonyms:	Nrxn1beta cKO
Gene:	Nrxn1  Location: Chr17:90341059-91400499 bp, - strand  Genetic Position: Chr17, 59.73 cM
Alliance:	Nrxn1tm2Sud page

Germline Transmission:	Earliest citation of germline transmission: J:224592
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into the 5' end of a modified exon 18, which contains an EGFP reporter gene followed by FRT-flanked neomycin resistance cassette and a loxP site. Flp-mediated recombination removed the selection cassette and left the modified exon 18 floxed. The GFP insert does not affect the expression of neurexin 1 gene, but it is very difficult to detect GFP signals in the tissue by immunohistochemistry or direct fluorescence. (J:224592)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn1 Mutation:	95 strains or lines available

Original:	J:224592 Anderson GR, et al., beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30;162(3):593-606
All:	12 reference(s)