Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fzd5tm2Nat
Name:	frizzled class receptor 5; targeted mutation 2, Jeremy Nathans
MGI ID:	MGI:3796577
Synonyms:	Fz5CKO-AP
Gene:	Fzd5  Location: Chr1:64769717-64776907 bp, - strand  Genetic Position: Chr1, 32.74 cM
Alliance:	Fzd5tm2Nat page

Germline Transmission:	Earliest citation of germline transmission: J:136390
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted downstream of exon 1 and a cassette containg a 5' loxP site, alkaline phosphatase gene and an frt-flanked neo gene was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed and the alkaline phosphatase gene intact. This is a floxed allele and a reporter allele. (J:136390)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd5 Mutation:	33 strains or lines available

Original:	J:136390 Liu C, et al., An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci. 2008 May 28;28(22):5641-53
All:	6 reference(s)