Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Best2tm1Dgen
Name:	bestrophin 2; targeted mutation 1, Deltagen
MGI ID:	MGI:3796232
Synonyms:	Best2tm1Amar
Gene:	Best2  Location: Chr8:85733831-85741160 bp, - strand  Genetic Position: Chr8, 41.46 cM
Alliance:	Best2tm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:136137
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 containing the translation initiation methionine through part of exon 3 was replaced with a lacZ-neo cassette. The absence of protein product was confirmed by immunohistochemistry of colon and eye tissue. This is a null allele and a reporter allele. (J:136137)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Best2 Mutation:	29 strains or lines available

Original:	J:136137 Bakall B, et al., Bestrophin-2 is involved in the generation of intraocular pressure. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1563-70
All:	6 reference(s)