Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr5a2tm1Sakl
Name:	nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Steven A Kliewer
MGI ID:	MGI:3795276
Synonyms:	LRH-1floxed
Gene:	Nr5a2  Location: Chr1:136770309-136888186 bp, - strand  Genetic Position: Chr1, 59.98 cM, cytoband E4
Alliance:	Nr5a2tm1Sakl page

Germline Transmission:	Earliest citation of germline transmission: J:135822
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5 and an additional loxP site was inserted upstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:135822)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr5a2 Mutation:	94 strains or lines available

Original:	J:135822 Lee YK, et al., Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol. 2008 Jun;22(6):1345-56
All:	6 reference(s)