Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atxn2tm1.1Aub
Name:	ataxin 2; targeted mutation 1.1, Georg Auburger
MGI ID:	MGI:3793867
Synonyms:	Atxn2tm1.1Geno, Sca2-
Gene:	Atxn2  Location: Chr5:121849672-121954372 bp, + strand  Genetic Position: Chr5, 61.93 cM, cytoband F
Alliance:	Atxn2tm1.1Aub page

Germline Transmission:	Earliest citation of germline transmission: J:135320
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient cre expression in ES cells ws used to remove exon 1 and the neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:135320)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atxn2 Mutation:	87 strains or lines available

Original:	J:135320 Lastres-Becker I, et al., Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet. 2008 May 15;17(10):1465-81
All:	8 reference(s)