Tg(H2-Ea*deltaX)16Dim
Transgene Detail
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Symbol: |
Tg(H2-Ea*deltaX)16Dim |
Name: |
transgene insertion 16, Diane Mathis |
MGI ID: |
MGI:3793642 |
Synonyms: |
Tg(dX21,16)3Strasbourg, WEdeltaX21, WEdeltaX21-16 |
Transgene: |
Tg(H2-Ea*deltaX)16Dim Location: unknown
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Alliance: |
Tg(H2-Ea*deltaX)16Dim page
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Strain of Origin: |
(C57BL/6 x SJL)F2
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(H2-Ea*deltaX)16Dim expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
H2-I (MGI:95903) |
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Mutation details: A 9 kb fragment of the H2-Ea(k) from the A/J mouse (clone lambdaA/J p34.13) was modified at 3 positions creating the WE32 construct (modified H2-Ea). This was used as the basis for a mutant H2-Ea gene having a deletion of the X box (from position -93 to -80). The resulting 8.2 kb transgenic construct WEdeltaX21 was injected into (C57BL/6 x SJL)F2 embryo pronuclei. Multiple lines - 5. 16, 23, and 24, were derived, and 16 was donated to The Jackson Laboratory. S1 nuclease mapping shows that H2-Ea mRNA is expressed in the spleen but initiation of most transcripts is aberrant, occurring at scattered positions throughout the 5' end.
(J:135138)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:135138 Dorn A, et al., Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6249-53 |
All: |
1 reference(s) |
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