Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Bdkrb1tm2Bdr
Name:	bradykinin receptor, beta 1; targeted mutation 2, Michael Bader
MGI ID:	MGI:3790746
Synonyms:	B1B2-
Gene:	Bdkrb1  Location: Chr12:105570350-105571770 bp, + strand  Genetic Position: Chr12, 55.81 cM, cytoband F1
Alliance:	Bdkrb1tm2Bdr page

Germline Transmission:	Earliest citation of germline transmission: J:134859
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region was replaced with a hygro cassette in ES cells containing Bdkrb2tm1Jfh. The absence of either transcript was confirmed by RT-PCR in stomach, ileum, kidney, heart, brain and lung extracts. (J:134859)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bdkrb1 Mutation:	21 strains or lines available

Original:	J:134859 Cayla C, et al., Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J. 2007 Jun;21(8):1689-98
All:	7 reference(s)