Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Cdsntm1Mmat Name: corneodesmosin; targeted mutation 1, Mitsuru Matsumoto MGI ID: MGI:3790339 Gene: Cdsn  Location: Chr17:35863025-35868077 bp, + strand  Genetic Position: Chr17, 18.7 cM Alliance: Cdsntm1Mmat page

Cdsntm1Mmat/Cdsntm1Mmat mice exhibit stratum corneum detachment due to defective desmosome formation Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:134613
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 and all of exon 2 were replaced with a LacZ-neo fusion gene via homologous recombination. Western blot analysis confirmed the absence of protein in homozygous skin. (J:134613)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdsn Mutation:	21 strains or lines available

Original:	J:134613 Matsumoto M, et al., Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6720-4
All:	1 reference(s)