Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tob2tm1Tya
Name:	transducer of ERBB2, 2; targeted mutation 1, Tadashi Yamamoto
MGI ID:	MGI:3789484
Gene:	Tob2  Location: Chr15:81732473-81742997 bp, - strand  Genetic Position: Chr15, 38.26 cM, cytoband E2
Alliance:	Tob2tm1Tya page

Germline Transmission:	Earliest citation of germline transmission: J:134287
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region was replaced with a lacZ gene with a nuclear localization signal and a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on embryonic fibroblast extracts. This is a null allele and a reporter allele. (J:134287)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tob2 Mutation:	22 strains or lines available

Original:	J:134287 Ajima R, et al., Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008 Apr 16;582(9):1313-8
All:	3 reference(s)