Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Ins2-E3*704)2Dvs
Name:	transgene insertion 2, David V Serreze
MGI ID:	MGI:3785496
Synonyms:	DL704, RIPE3704
Transgene:	Tg(Ins2-E3*704)2Dvs  Location: unknown
Alliance:	Tg(Ins2-E3*704)2Dvs page

Strain of Origin:

NOD/ShiLtDvs

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Mutation details: The rat insulin promoter was placed upstream of the adenovirus early region 3 (E3) with a 202-bp deletion of the gp19K gene and the sequences for the 10.4K, 14.5K, 14.7K (and 11.6K) genes retained. This construct was injected into NOD/ShiLtDvs oocytes. RT-PCR analysis of mRNA from pancreatic beta cells of mice bearing this transgene demonstrates expression of the 10.4K, 14.5K, 14.7K and 11.6K genes, but detects no gp19 transcripts. (J:83195)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:83195 Pierce MA, et al., Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes. 2003 May;52(5):1119-27
All:	1 reference(s)