Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Erc2tm1.1Sud
Name:	ELKS/RAB6-interacting/CAST family member 2; targeted mutation 1.1, Thomas C Sudhof
MGI ID:	MGI:3783990
Synonyms:	E2X, ELKS2alpha-
Gene:	Erc2  Location: Chr14:27344385-28200494 bp, + strand  Genetic Position: Chr14, 16.51 cM
Alliance:	Erc2tm1.1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:133656
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was used to place a loxP site in the 5' UTR of the gene in the AflII restriction site 70 bp 5' of the ATG. A tetracysteine tag was inserted in frame into the first coding exon (from GGLSGSS to GGLSGCCPGCCSGSS) and an frt-neo-frt-loxp cassette was inserted 110 bp downstream of exon 1 into the genomic NdeI site. The line was crossed to cre-transgenic mice to excise the first coding exon. Total brain protein levels are normal. Rims1 is 30% more soluble in a detergent-free fractionation. (J:133656)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Erc2 Mutation:	112 strains or lines available

Original:	J:133656 Sudhof TC, Generation of an Erc2 mutant allele. MGI Direct Data Submission. 2008;
All:	3 reference(s)