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Grhl1tm1Jane
Targeted Allele Detail
Summary
Symbol: Grhl1tm1Jane
Name: grainyhead like transcription factor 1; targeted mutation 1, Stephen M Jane
MGI ID: MGI:3778923
Gene: Grhl1  Location: Chr12:24622282-24667390 bp, + strand  Genetic Position: Chr12, 8.49 cM
Alliance: Grhl1tm1Jane page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133318
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR on brain, kidney, testis, lung, stomach, liver, spleen, thymus, heart, and skin extracts. This is a null allele. (J:133318)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grhl1 Mutation:  33 strains or lines available
References
Original:  J:133318 Wilanowski T, et al., Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J. 2008 Mar 19;27(6):886-97
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory