Del(6Ephb6-Trpv6)1Mhed
Targeted Allele Detail
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| Symbol: |
Del(6Ephb6-Trpv6)1Mhed |
| Name: |
deletion, Chr 6, Matthias Hedinger 1 |
| MGI ID: |
MGI:3778644 |
| Synonyms: |
Del1Mhed, Ephb6/Trpv6tm1Mhed |
| Gene: |
Del(6Ephb6-Trpv6)1Mhed Location: unknown Genetic Position: Chr6, Syntenic
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| Germline Transmission: |
Earliest citation of germline transmission:
J:133151
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion, Intragenic deletion
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Del(6Ephb6-Trpv6)1Mhed involves 2 genes/genome features (Ephb6, Trpv6)
View all
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Mutation details: Part of intron 6, exon 7 and exon 8 and part of exon 9 were replaced with a neo cassette. This replaces most of the coding region from the transmembrane domain to the end of the protein. The absence of protein product was confirmed by western blot analysis on intestine extracts. The gene targeting also replaces the last 4 exons of Ephb6 that encode the SAM domain and part of the kinase domain. No molecular evidence is presented as to the effect of this deletion.
(J:133151)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Del(6Ephb6-Trpv6)1Mhed Mutation: |
0 strains or lines available
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| Original: |
J:133151 Bianco SD, et al., Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb;22(2):274-85 |
| All: |
8 reference(s) |
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Analysis Tools
