Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rnf5tm1Zron
Name:	ring finger protein 5; targeted mutation 1, Ze'ev Ronai
MGI ID:	MGI:3775796
Gene:	Rnf5  Location: Chr17:34820073-34822535 bp, - strand  Genetic Position: Chr17, 18.18 cM
Alliance:	Rnf5tm1Zron page

Germline Transmission:	Earliest citation of germline transmission: J:132185
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1, 2 and 3 were replaced with a neo cassette. This deletion spans the translation initiation site and the RING domain encoding exon. The absence of protein product was confirmed by western blot analysis on tibialis muscle extrtacts. (J:132185)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf5 Mutation:	24 strains or lines available

Original:	J:132185 Delaunay A, et al., The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis. PLoS One. 2008;3(2):e1609
All:	6 reference(s)