Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kpna1Gt(P017E08)Wrst
Name:	karyopherin subunit alpha 1; gene trap P017E08, Wolfgang Wurst
MGI ID:	MGI:3775202
Synonyms:	Impalpha5-
Gene:	Kpna1  Location: Chr16:35803693-35859479 bp, + strand  Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
Alliance:	Kpna1Gt(P017E08)Wrst page

Mutant Cell Line:	P017E08
Germline Transmission:	Earliest citation of germline transmission: J:131958
Parent Cell Line:	IDG3.2 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: FlipROSAbetageo   Mutation details: A gene trap vector (containing the betageo fusion gene) was inserted into the gene resulting in a null allele. The absence of protein product was confirmed by western blot analysis on testis, spleen, brain, lung and heart extracts. (J:131958) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select P017E08 CL301863 (MGI Seq Detail) 5' RACE Chr16:35803701-35803877 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 22 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kpna1 Mutation:	67 strains or lines available

Original:	J:131958 Shmidt T, et al., Normal brain development in importin-alpha5 deficient-mice. Nat Cell Biol. 2007 Dec;9(12):1337-8; author reply 1339
All:	7 reference(s)