Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-TAg)1Efr
Name:	transgene insertion 1, Shimon Efrat
MGI ID:	MGI:3770670
Synonyms:	tet-TAg
Transgene:	Tg(tetO-TAg)1Efr  Location: unknown
Alliance:	Tg(tetO-TAg)1Efr page

Strain of Origin:

C3HeB/FeJ

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Mutation details: To generate the transgene, a fragment containing a tandem array of 7 copies of the tetracycline operator sequence and a cytomegalovirus minimal promoter was placed in front of the SV40 large T antigen gene. The promoter does not allow expression of the TAg gene, and transgenic mice do not develop tumors, unless crossed with mice expressing a tetracycline transactivator gene (tTA or rtTA). (J:56326)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:56326 Efrat S, et al., Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3576-80
All:	7 reference(s)