Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd79btm3Mnz
Name:	CD79B antigen; targeted mutation 3, Michel C Nussenzweig
MGI ID:	MGI:3768659
Gene:	Cd79b  Location: Chr11:106202167-106205388 bp, - strand  Genetic Position: Chr11, 68.89 cM
Alliance:	Cd79btm3Mnz page

Germline Transmission:	Earliest citation of germline transmission: J:128768
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The cytoplasmic tail from amino acid position 183 to 228 was replaced with the cytoplasmic tail of Cd79a from amino acid position 161 to 220. A stop codon follows the last amino acid of the inserted Cd79a segment. A floxed neo cassette was inserted downstream of the Ig domain and subsequently removed by cre-mediated recombination. The presence of the modified protein and the absence of the full length endogenous transcript was confirmed by western blot analysis on B cell lysates. (J:128768)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd79b Mutation:	36 strains or lines available

Original:	J:128768 Reichlin A, et al., A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells. J Exp Med. 2004 Mar 15;199(6):855-65
All:	1 reference(s)