Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rims2tm1.2Schc
Name:	regulating synaptic membrane exocytosis 2; targeted mutation 1.2, Susanne Schoch
MGI ID:	MGI:3762950
Synonyms:	RIM2a inducible KO, RMF
Gene:	Rims2  Location: Chr15:39061681-39547768 bp, + strand  Genetic Position: Chr15, 15.45 cM, cytoband C
Alliance:	Rims2tm1.2Schc page

Germline Transmission:	Earliest citation of germline transmission: J:119934
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to flank exon 5 of the gene with loxP sites and insert an FRT-flanked neomycin resistance cassette in reverse orientation in intron 4 (within the loxP sites). Mice carrying the mutation were crossed with a FLP strain on a C57BL/6 and 129 mixed background driven by an actin promoter. The neomycin cassette was excised, leaving the floxed exon. (J:119934)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rims2 Mutation:	250 strains or lines available

Original:	J:119934 Schoch S, et al., Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 Dec 13;25(24):5852-63
All:	1 reference(s)