Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gatad2atm1Rnu Name: GATA zinc finger domain containing 2A; targeted mutation 1, Roel Nusse MGI ID: MGI:3762633 Synonyms: mp66alpha null, p66 KO Gene: Gatad2a  Location: Chr8:70359726-70449034 bp, - strand  Genetic Position: Chr8, 34.06 cM Alliance: Gatad2atm1Rnu page

Gatad2atm1Rnu/Gatad2atm1Rnu mutant embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:126871
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 2-4 with a loxP-flanked neomycin resistance (pgk-neo) cassette. This mutation introduced a stop codon before the coiled-coil region (CR1) region of the gene. In order to remove the floxed pgk-neo cassette, heterozygous mutant females were crossed to a CMV-cre male on a mixed C57BL/6-129SV background. (J:126871)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gatad2a Mutation:	125 strains or lines available

Original:	J:126871 Marino S, et al., Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal. PLoS One. 2007;2(6):e519
All:	1 reference(s)