Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cbfbtm1Itan
Name:	core binding factor beta; targeted mutation 1, Ichiro Taniuchi
MGI ID:	MGI:3761812
Synonyms:	Cbfbetaf, Cbfbetaflox
Gene:	Cbfb  Location: Chr8:105897306-105944621 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Cbfbtm1Itan page

Germline Transmission:	Earliest citation of germline transmission: J:125953
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin resistance cassette was placed adjacent to exon 5 and a loxP site was placed in the other flanking intron. The neomycin resistance cassette was subsequently removed by transient expression of Cre recombinase, leaving exon 5 flanked by loxP sites (J:125953)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cbfb Mutation:	36 strains or lines available

Original:	J:125953 Naoe Y, et al., Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007 Aug 6;204(8):1749-55
All:	43 reference(s)