Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(CD74)AR194Ayr
Name:	transgene insertion AR194, Alexander Y Rudensky
MGI ID:	MGI:3760406
Synonyms:	hIi, hIiWT
Transgene:	Tg(CD74)AR194Ayr  Location: unknown
Alliance:	Tg(CD74)AR194Ayr page

Strain of Origin:

(C57BL/6J x DBA/2J)F1 x C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CD74)AR194Ayr expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CD74 (972) Cd74  (MGI:96534)   Mutation details: A vector containing the human class II-associated invariant chain gene (hIi, CD74) and promoter was injected into (C57BL/6J x DBA/2J)F1 x C57BL/6J embryos. This line (AR194) was initially backcrossed to C57BL/6-congenic invariant chain targeted mutant mice and later crossed with inbred C57BL/6 animals for a total of more than 12 generations by the donating investigator. This line no longer carries the invariant chain targeted mutation. (J:88717)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:88717 Honey K, et al., Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. J Immunol. 2004 Apr 1;172(7):4142-50
All:	1 reference(s)