Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adora2btm1Till
Name:	adenosine A2b receptor; targeted mutation 1, Stephen Tilley
MGI ID:	MGI:3759856
Synonyms:	A2b-
Gene:	Adora2b  Location: Chr11:62139810-62157278 bp, + strand  Genetic Position: Chr11, 37.96 cM, cytoband B2
Alliance:	Adora2btm1Till page

Germline Transmission:	Earliest citation of germline transmission: J:125297
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of the intron and all of exon 2 were replaced with a PGK-neo cassette to create a null allele. The absence of transcript was confirmed by RT-PCR and the absence of protein product was confirmed by western blot of protein extracts from the brain and kidney. (J:125297)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adora2b Mutation:	19 strains or lines available

Original:	J:125297 Hua X, et al., Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. J Exp Med. 2007 Jan 22;204(1):117-28
All:	11 reference(s)