Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cln3tm1Blda
Name:	CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Beverly L Davidson
MGI ID:	MGI:3759415
Synonyms:	Cln3lacZ
Gene:	Cln3  Location: Chr7:126170571-126184991 bp, - strand  Genetic Position: Chr7, 69.16 cM
Alliance:	Cln3tm1Blda page

Germline Transmission:	Earliest citation of germline transmission: J:125194
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Genomic sequence from the ATG in exon 1 through exons 8 was replaced with a beta-gal-pA and TKPneo cassette then knocked into the open reading frame to produce a null reporter allele. Expression of the lacZ was confirmed by X-gal assay and the absence of a transcript was confirmed RT-PCR. (J:125194)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cln3 Mutation:	38 strains or lines available

Original:	J:125194 Eliason SL, et al., A knock-in reporter model of Batten disease. J Neurosci. 2007 Sep 12;27(37):9826-34
All:	8 reference(s)