Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dlgap3tm1Gfng
Name:	DLG associated protein 3; targeted mutation 1, Guoping Feng
MGI ID:	MGI:3759300
Synonyms:	Sapap3-
Gene:	Dlgap3  Location: Chr4:127062997-127130815 bp, + strand  Genetic Position: Chr4, 61.33 cM
Alliance:	Dlgap3tm1Gfng page

Germline Transmission:	Earliest citation of germline transmission: J:125181
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 containing the translation initiation codon was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis of brain lysate and postsynaptic density fraction. (J:125181)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlgap3 Mutation:	84 strains or lines available

Original:	J:125181 Welch JM, et al., Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature. 2007 Aug 23;448(7156):894-900
All:	23 reference(s)