Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Pds5btm1Jmi Name: PDS5 cohesin associated factor B; targeted mutation 1, Jeffrey Milbrandt MGI ID: MGI:3722688 Synonyms: Psd5b- Gene: Pds5b  Location: Chr5:150597204-150734155 bp, + strand  Genetic Position: Chr5, 89.61 cM Alliance: Pds5btm1Jmi page

Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg Pds5btm1Jmi/Pds5b+ and Pds5aGt(RRM243)Byg/Pds5a+ Pds5btm1Jmi/Pds5btm1Jmi mice display abnormal lens development Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:124279
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region of the second exon is replaced by a betagal/pgk-neo cassette. The floxed neo was removed via cre mediated recombination. Protein was not detected in mutants by immunoblot analysis. (J:124279)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pds5b Mutation:	100 strains or lines available

Original:	J:124279 Zhang B, et al., Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development. 2007 Sep;134(17):3191-201
All:	3 reference(s)