Nlrp3tm1Tsc
Targeted Allele Detail
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| Symbol: |
Nlrp3tm1Tsc |
| Name: |
NLR family, pyrin domain containing 3; targeted mutation 1, Jurg Tschopp |
| MGI ID: |
MGI:3721141 |
| Synonyms: |
NALP3- |
| Gene: |
Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
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| Alliance: |
Nlrp3tm1Tsc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:124226
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: The gene was disrupted by the insertion of an EGFP cassette fused in frame with the ATG of exon 2. A selection cassette PGK-neo flanked by 2 loxP sites was also inserted in the intron 2. The neo cassette was deleted by backcrossing the mice with a Cre-expressing deleter strain. RT-PCR analysis of RNA isolated from mutant macrophages confirmed that the wild-type transcript is absent.
(J:124226)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nlrp3 Mutation: |
61 strains or lines available
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| Original: |
J:124226 Martinon F, et al., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006 Mar 9;440(7081):237-41 |
| All: |
136 reference(s) |
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Analysis Tools
