Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-KLF4)32831Rup
Name:	transgene insertion 32831, J Michael Ruppert
MGI ID:	MGI:3717763
Synonyms:	TRE-KLF4, TRE-KLF432831
Transgene:	Tg(tetO-KLF4)32831Rup  Location: unknown
Alliance:	Tg(tetO-KLF4)32831Rup page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-KLF4)32831Rup expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human KLF4 (9314) Klf4  (MGI:1342287)   Mutation details: The protein-coding region of the human Kruppel-like factor gene KLF4 was ligated to a vector fragment containing a tetracycline-responsive element and the minimal human cytomegalovirus promoter to produce the transgene construct. The 4.4 kb fragment was injected into (C57BL/6 x SJL)F2 ova. (J:96886)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:96886 Foster KW, et al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500
All:	2 reference(s)