Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tsc2tm1.1Mjg
Name:	TSC complex subunit 2; targeted mutation 1.1, Michael J Gambello
MGI ID:	MGI:3712063
Synonyms:	Tsc2flox
Gene:	Tsc2  Location: Chr17:24814790-24851604 bp, - strand  Genetic Position: Chr17, 12.41 cM
Alliance:	Tsc2tm1.1Mjg page

Germline Transmission:	Earliest citation of germline transmission: J:121748
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: This allele contains loxP sites flanking exons 2, 3 and 4. A frt-flanked neomycin selection cassette was removed from the first intron by crossing with mice expressing FLP recombinase in the germline, leaving a single frt site downstream of the first loxP site. (J:121748)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Tsc2tm1.1Mjg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:	77 strains or lines available

Original:	J:121748 Hernandez O, et al., Generation of a conditional disruption of the Tsc2 gene. Genesis. 2007 Feb;45(2):101-6
All:	58 reference(s)