Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tg(HLA-A/H2-D/B2M)1Dvs
Name:	transgene insertion 1, David Serreze
MGI ID:	MGI:3711057
Synonyms:	HDD, HHD
Transgene:	Tg(HLA-A/H2-D/B2M)1Dvs  Location: unknown
Alliance:	Tg(HLA-A/H2-D/B2M)1Dvs page

Strain of Origin:

NOD/ShiLtDvs

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HLA-A/H2-D/B2M)1Dvs expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human B2M (567) B2m  (MGI:88127)   Mutation details: This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line. (J:41077, J:121685)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available      Cell Lines: 0 lines available

Original:	J:121685 Takaki T, et al., HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol. 2006 Mar 1;176(5):3257-65
All:	21 reference(s)