Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(tetO-APPSwInd)102Dbo
Name:	transgene insertion 102, David R Borchelt
MGI ID:	MGI:3708167
Synonyms:	tet-APPswe/ind (line 102), tet-APPswe/ind line 102, Tg(tetO-APP*Swe*Ind)102Dbo
Transgene:	Tg(tetO-APPSwInd)102Dbo  Location: unknown
Alliance:	Tg(tetO-APPSwInd)102Dbo page

Strain of Origin:

(C57BL/6J x C3H/HeJ)F1

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-APPSwInd)102Dbo expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse App (MGI:88059) The gene encodes a humanized amyloid beta domain and incorporates the Swedish and Indiana mutations.   Tg(tetO-APPSwInd)102Dbo expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified tetO   Mutation details: The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Line 102 was established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. (J:80782, J:109829)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:109829 Jankowsky JL, et al., Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec;2(12):e355
All:	22 reference(s)