Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(APOC3)3707Bres
Name:	transgene insertion 3707, Jan L Breslow
MGI ID:	MGI:3703618
Synonyms:	HuCIII Tg
Transgene:	Tg(APOC3)3707Bres  Location: unknown
Alliance:	Tg(APOC3)3707Bres page

Strain of Origin:

(C57BL/6J x CBA/J)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(APOC3)3707Bres expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human APOC3 (345) Apoc3  (MGI:88055)   Mutation details: Male pronuclei of fertilized oocytes were microinjected with a transgenic construct comprising the human apolipoprotein C-III gene, including 2.5 kb of 5' and 1.1 kb of 3' flanking sequence. Mice of this line express the transgene at high levels in the liver and secondarily in the intestine. (J:81184)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:81184 Ito Y, et al., Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science. 1990 Aug 17;249(4970):790-3
All:	23 reference(s)