Lemd3<Gt(XST167)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3703328)

Lemd3^{Gt(XST167)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Lemd3^{Gt(XST167)Byg}
Name:	LEM domain containing 3; gene trap XST167, BayGenomics
MGI ID:	MGI:3703328
Synonyms:	Man1^delta
Gene:	Lemd3 Location: Chr10:120759318-120815237 bp, - strand Genetic Position: Chr10, 68.88 cM
Alliance:	Lemd3^{Gt(XST167)Byg} page

Mutation
origin

Mutant Cell Line:	XST167
Germline Transmission:	Earliest citation of germline transmission: J:119566
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap

Mutation details: The pGT1Mpfs gene trap vector inserted into intron 4 of the locus, deleting the C-terminal region containing the Smad-interaction domain. Western blot failed to detect wild-type protein from mutants. (J:119566)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lemd3 Mutation:	36 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:119566 Ishimura A, et al., Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct;133(19):3919-28
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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