Summary | Transgene origin | Transgene description | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Name:	transgene insertion A6, Corinne G Lobe
MGI ID:	MGI:3703164
Synonyms:	iZ/EG-TEL-AML1, Tg(ACTB-Bgeo,-TEL/AML1,-EGFP)A6Lbe, Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Transgene:	Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe  Location: unknown
Alliance:	Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe page

Germline Transmission:	Earliest citation of germline transmission: J:119130
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: A transgenic construct was designed with the CMV enhancer/chicken beta-actin promoter, loxP-flanked STOP sequence (beta-geo reporter followed by SV40 polyadenylation signal), human TEL-AML1 fusion protein sequence (coding for the translocation t(12;21)(p13;q22)), internal ribosomal entry site, and an enhanced green fluorescent protein (EGFP) gene. Prior to Cre-mediated excision of the "floxed" STOP sequence, high expression of lacZ is observed in cells and tissues. When bred to Cre recombinase expressing mice, the STOP sequence (and beta-geo) is removed in the resulting offspring, allowing transcription/co-expression of both the human TEL-AML1 fusion protein and EGFP to proceed in the Cre recombinase expressing cells. (J:119130)

List all tumor models in MMHCdb carrying Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:119130 Yang W, et al., TEL-AML1 transgene expression in hematopoietic cells produces lymphoblastic leukemia in mice. MGI Direct Data Submission. 2007;
All:	2 reference(s)