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Anpeptm1Sid
Targeted Allele Detail
Summary
Symbol: Anpeptm1Sid
Name: alanyl aminopeptidase, membrane; targeted mutation 1, Richard L Sidman
MGI ID: MGI:3702506
Synonyms: APN-, Lap1tm1Sid
Gene: Anpep  Location: Chr7:79471551-79497958 bp, - strand  Genetic Position: Chr7, 45.19 cM
Alliance: Anpeptm1Sid page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119474
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 6 were replaced with an IRES-LacZ, floxed PGK-neo cassette. The null allele was confirmed by the absence of mRNA and protein in brain, kidney, spleen, liver, pancrease, intestine and ovary tissue as detected by RT-PCR and immunohistochemistry, respectively. (J:119474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 26 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anpep Mutation:  81 strains or lines available
References
Original:  J:119474 Rangel R, et al., Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4588-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory