Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mug1tm2Vln
Name:	murinoglobulin 1; targeted mutation 2, Fred Van Leuven
MGI ID:	MGI:3700943
Synonyms:	MAM-/MUG-1-
Gene:	Mug1  Location: Chr6:121815500-121866016 bp, + strand  Genetic Position: Chr6, 57.52 cM, cytoband F2
Alliance:	Mug1tm2Vln page

Germline Transmission:	Earliest citation of germline transmission: J:57485
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A targeting construct containing a neomycin resistance gene was inserted into ES cells containing a previously targeted insertion of a hygromycin cassette into exon 17 of the Pzp locus. Deficiency of both proteins was confirmed by Northern blot of mutant liver samples. (J:57485)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mug1 Mutation:	115 strains or lines available

Original:	J:57485 Umans L, et al., alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. Am J Pathol. 1999 Sep;155(3):983-93
All:	3 reference(s)